4F-PHP

4F-PHP

4F-PHP is an analog of the compound alpha-pyrrolidinohexiophenone from its parent compound by having the aromatic ring fluorinated. Many of the cathinone compounds have stimulatory effects when consumed. Some induce states of euphoria and some act as entactogens. Fluorination of drug compounds can sometimes increase bioavailability and lipophilicity and the highly electronegative character of fluorine can change the topographical charge of the molecule interfering with metabolism and giving the compound a longer half-life.

The nitrogen itself is transformed into a pyrrolidine moiety as it forms a five member ring with four other carbons. They are related to the chemical compound cathinone. The substituted cathinones are a series of compounds which feature a phenethylamine backbone with a ketone at the beta carbon and various alkyl moieties substituted at the alpha carbon adjacent to the amine. 4F-PVP and α-PHP have a butyl substitute at the alpha carbon. This confers increased lipophilicity to these particular cathinones, electronegative fluorine atom should make the carbonyl less polar.