JWH-018

JWH-018 (1-pentyl-3-(1-naphthoyl)indole) or AM-678  is an analgesic chemical from the naphthoylindole family. Further more, They acts as a full agonist at both the CB₁ and CB₂ cannabinoid receptors, with some selectivity for CB₂. buy jwh 018 online. It produces effects in animals similar to those of tetrahydrocannabinol (THC). where to buy jwh 018 online. Further more, Cannabinoid naturally present in cannabis, leading to its use in synthetic cannabis products. In some countries are sold legally as “incense blends”. buy jwh 018 powder.

Where can i purchase jwh 018. As a full agonist at both the CB₁ and CB₂ cannabinoid receptors. In addition, This chemical compound is classified as an analgesic medication. The analgesic effects of cannabinoid ligands, mediated by CB1 receptors are well. In Addition,  established in treatment of neuropathic pain, as well as cancer pain and arthritis. buy jwh 018 online.

These compounds work by mimicking the body’s naturally-produced endocannabinoid hormones such as 2-AG and anandamide (AEA), which are biologically active and can exacerbate or inhibit nerve signalling. As the cause is poorly understood in chronic pain states, more research and development must be done before the therapeutic potential of this class of biologic compounds can be realized. where to buy jwh 018 online.

At least one case of JWH-018 dependence has been reported by the media. The user consumed JWH-018 daily for eight months. Withdrawal symptoms were more severe than those experienced as a result of cannabis dependence. JWH-018 has been shown to cause profound changes in CB₁ receptor density following administration, causing desensitization to its effects more rapidly than related cannabinoids

Various physical and psychological adverse effects have been reported from JWH-018 use. One study reported psychotic relapses and anxiety symptoms in well-treated patients with mental illness following JWH-018 inhalation. Due to concerns about the potential of JWH-018 and other synthetic cannabinoids to cause psychosis in vulnerable individuals, it has been recommended that people with risk factors for psychotic illnesses (like a past or family history of psychosis) not use these substances